The Obestatin/Ghrelin System as a Novel Regulatory Mechanism of Iris Muscle Contraction

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The obestatin/ghrelin system as a novel regulatory mechanism of iris muscle contraction.

PURPOSE To evaluate obestatin and ghrelin effects on iris muscle contraction. MATERIALS AND METHODS Obestatin (10(-5) M) or ghrelin (10(-5) M) were tested on two consecutive carbachol-or epinephrine-elicited contractions of iris rabbit sphincter or dilator muscles. Ghrelin and obestatin effects on iris muscles basal tension were also tested, and their effects on iris sphincter EFS-elicited co...

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Calcium ion-insensitive contraction of glycerinated porcine cardiac muscle fibers by Mg-inosine triphosphate. ITP as a tool to dissociate the contraction mechanism from the regulatory mechanism.

The contraction of cardiac muscle that has been treated with glycerol requires Ca2+ (pCa 8-5), when MgATP is used as a substrate. In contrast, this preparation contracts, even in the absence of Ca2+ (pCa 8-10), when ATP is replaced by ITP. Ca2+ dependency was not observed after increasing free Ca2+ concentrations from pCa 8.0 to 5.0, or after increasing MgITP concentration from 5 to 80 mM. On t...

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Calcium Ion-Insensitive Contraction of Glycerinated Porcine Cardiac Muscle Fibers by Mg-Inosine Triphosphate FTP as a Tool to Dissociate the Contraction Mechanism from the Regulatory Mechanism

The contraction of cardiac muscle that has been treated with glycerol requires Ca (pCa 8-5), when MgATP is used as a substrate. In contrast, this preparation contracts, even in the absence of Ca (pCa 8-10), when ATP is replaced by ITP. Ca dependency was not observed after Increasing free Ca concentrations from pCa 8.0 to 5.0, or after increasing MgTTP concentration from A to 80 mM. On the other...

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ژورنال

عنوان ژورنال: Current Eye Research

سال: 2008

ISSN: 0271-3683,1460-2202

DOI: 10.1080/02713680701791058